New Drug Protein Targets
These drug targets relate to the particular protein in the body which is key to the drug's activity.
The drug binding to a particular protein may act to inhibit or activate said protein. However, in the case of protein replacement or gene therapies, or certain vaccines, the drug or its expression product will be the target. Many of these targets may have a Target Family assigned to them; this is a way of grouping together protein targets by their activity, such as enzyme types (including protein kinases), receptors, cytokines, ion channels, peptide hormones, or transporters.
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June 2008 Drug Targets
amine oxidase (flavin containing) domain 2
keratin 6A
glutamate receptor, metabotropic 7
klotho beta
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May 2008 Drug Targets
polo-like kinase 3 (Drosophila)
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April 2008 Drug Targets
oncomodulin
prostaglandin D2 synthase, hematopoietic
pyruvate kinase, muscle
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March 2008 Drug Targets
activin A receptor type II-like 1
CD9 molecule
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January 2008 Drug Targets
indoleamine-pyrrole 2,3 dioxygenase
peptidylprolyl isomerase B (cyclophilin B)
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December 2007 Drug Targets
protease, serine, 12 (neurotrypsin, motopsin)
glutamate receptor, metabotropic 4
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November 2007 Drug Targets
myristoylated alanine-rich protein kinase C substrate
MAP kinase interacting serine/threonine kinase 1
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October 2007 Drug Targets
angiopoietin 1
inducible T-cell co-stimulator ligand
protein kinase D1
protein kinase C, iota
protein kinase N1
ADAMTS 13
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September 2007 Drug Targets
interleukin 25
angiopoietin-like 4
bone morphogenetic protein 4
potassium voltage-gated channel, shaker-related subfamily, member 2
transient receptor potential cation channel, subfamily V, member 3
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August 2007 Drug Targets
caspase 2
CD163 molecule
interleukin 17 receptor C
lectin, galactoside-binding, soluble, 9 (galectin 9)
secreted frizzled-related protein 1
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July 2007 Drug Targets
Endogenous retroviral family W, env (C7), member 1 (syncytin)
G protein-coupled bile acid receptor 1
integrin, alpha 9
SHC (Src homology 2 domain containing) transforming protein 1
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
voltage-dependent anion channels 2 and 3
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June 2007 Drug Targets
circumsporozoite protein, Plasmodium yoelii
D-amino-acid oxidase
epoxide hydrolase 2, cytoplasmi
FK506 binding protein 8, 38kDa
hepatocyte erythrocyte protein 17 kDa, Plasmodium yoelii
peripherin 2 (retinal degeneration, slow)
potassium inwardly-rectifying channel, subfamily J, member 2
SLAM family member 6
v-raf murine sarcoma 3611 viral oncogene homologue
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May 2007 Drug Targets
3-phosphoinositide dependent protein kinase-1
CUB domain-containing protein 1
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Plexin domain-containing 1
solute carrier family 2, (facilitated glucose transporter) member 8
ubiquitin-activating enzyme E1C (UBA3 homologue, yeast)
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April 2007 Drug Targets
coagulation factor V (proaccelerin, labile factor)
cysteinyl leucotriene receptor 2
EPH receptor A1
exportin 1 (CRM1 homologue, yeast)
glycerol-3-phosphate acyltransferase, mitochondrial
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
v-akt murine thymoma viral oncogene homologue 3 (protein kinase B, gamma)
G protein-coupled receptor 109A
high mobility group AT-hook 1
inducible T-cell co-stimulator
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March 2007 Drug Targets
CD83 molecule
CD47 molecule
complement component C3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
germ cell associated 2 (haspin)
histone deacetylase 6
interleukin 1, alpha
melanoma antigen family A, 4
NOL1/NOP2/Sun domain family, member 2
transient receptor potential cation channel, subfamily V, member 4
tumour-associated calcium signal transducer 2
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February 2007 Drug Targets
cadherin 3, type 1, P-cadherin (placental)
Delta-like 4 (DLL4)
guanylate binding protein 1, interferon-inducible, 67kDa
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January 2007 Drug Targets
5-hydroxytryptamine (serotonin) receptor 5A (5- HT5A)
Acid phosphatase, prostate (PAP)
aldehyde dehydrogenase 2 family (mitochondrial)
Aurora kinase C
AXL receptor tyrosine kinase
dihydropyrimidinase-like 2 (CRMP-2)
hemochromatosis type 2 (juvenile) (HJV)
lectin, galactoside-binding, soluble, 1 (galectin-1)
leucine-rich repeat kinase 2
Low density lipoprotein-related protein 2 (megalin)
Pim-1 oncogene
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1A)
Preferentially expressed antigen in melanoma (PRAME)
Prokineticin receptor 1 and prokineticin 1
PTK7 protein tyrosine kinase 7
Superoxide dismutase 2, mitochondrial
Torsin family 1, member A (torsin A)
Tumour suppressor candidate 4
V-set domain containing T-cell activation inhibitor 1
Zona pellucida glycoprotein 3 (sperm receptor)(ZP3)
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December 2006 Drug Targets
Myo-inositol oxygenase
Protein kinase N3
Prostaglandin D2 synthase 21kDa (brain)
Angiopoietin-2
YME1L1 YME1-like 1 (S. cerevisiae)
Low density lipoprotein receptor-related protein
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November 2006 Drug Targets
Transportin 1 and karyopherin (importin) beta 1
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October 2006 Drug Targets
mannosidase, alpha, class 2B, member 1
arylsulfatase A (ARSA)
hepatitis A virus cellular receptor 1
calcium channel, voltage-dependent, alpha 1F subunit
collagen, type IV, alpha 3 (Goodpastures antigen) binding protein
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