Mar2008 Drug Protein Targets
activin A receptor type II-like 1
Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. Research has suggested a role in angiogenesis and mutations in ACVRL1 cause pulmonary hypertension and hemorrhagic telangiectasia type 2
- Pfizer is developing PF-3446962, a fully human MAb that inhibits ACVRL1 as an anticancer.
- ACVRL1 belongs to the Receptor > Cytokine > Tumour Necrosis Factor and Transforming Growth Factor Target Family Groups and its EC number is 2.7.11.30.
Its Entrez Gene ID is 94.
CD9 molecule
CD9 belongs to the transmembrane 4 superfamily or tetraspanin family of proteins and is known to complex with integrins and other members of the transmembrane 4 superfamily. Numerous roles have been described, including involvement in platelet activation and aggregation, cell adhesion, cell motility, tumour metastasis and gamete fusion and regulation of paranodal junction formation.
- AR-40A746.2.3 is an anti-CD9 cancer stem cell antibody, under development by ARIUS Research for the treatment of leukaemia.
- Its Entrez Gene ID is 928.
Pharmaprojects - New protein targets for drug development
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