Jun2007 Drug Protein Targets
circumsporozoite protein, Plasmodium yoelii
Circumsporozoite protein, Plasmodium yoelii is the most prominant surface antigen on the sporozoite of the malaria parasite, Plasmodium spp. The sporozoite is the infectious stage in the Plasmodium life cycle, the form in which malaria is passed from the mosquito vector to the mammalian host. Antibodies to this protein have been used in the field to detect exposure to malaria.
- Alza (Johnson & Johnson) and Inovio are developing a DNA malaria vaccine encoding CSP and HEP17 antigens to be delivered by in vivo electroporation-enhanced injection.
- The Entrez Gene ID for circumsporozoite protein, Plasmodium yoelii is 3830374.
D-amino-acid oxidase
D-amino-acid oxidase is a flavoprotein which uses FAD as its prosthetic group. It is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulates during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor.
- Sepracor is developing D-amino acid oxidase inhibitors for the treatment of schizophrenia.
- It belong to the Enzyme Target Family Group and its EC number is 1.4.3.3. Its Entrez Gene ID is 1610.
epoxide hydrolase 2, cytoplasmi
Epoxide hydrolase 2 - also known as soluble epoxide hydrolase - is found in both the cytosol and peroxisomes. It binds to specific epoxides and converts them to the corresponding dihydrodiols. Epoxides play important roles in the regulation of arterial pressure during angiotensin II-dependent hypertension.
- Arete Therapeutics is developing compounds that inhibit soluble epoxide hydrolase (sEH) for the treatment of angiotensin II-dependent hypertension and inflammatory diseases.
- Epoxide hydrolase 2 belongs to the Enzyme Target Family Group and its EC number is 3.3.2.10. Its Entrez Gene ID is 2053.
FK506 binding protein 8, 38kDa
FK binding proteins (FKBPs) are of central importance for the folding and functionality of proteins. FKBP38 is a member of the FKBP506 family and has been shown to reduce nerve cell death following strokes. The FKBP/FK506 complex exerts its immunosuppressive effects by inhibiting calcineurin and calmodulin-dependent serine/threonine phosphatase that functions as a critical signaling molecule during T-cell activation.
- KeyNeurotek, in collaboration with the Max Planck Society, Munich, Germany, is developing inhibitors of FKBP38 as a neuroprotective following stroke.
- FK506BP belongs to the Enzyme > Isomerase Target Family Group.
- Its Entrez Gene ID is 23770.
hepatocyte erythrocyte protein 17 kDa, Plasmodium yoelii
hepatocyte erythrocyte protein 17 kDa, Plasmodium yoelii is a target of protective antibodies and T-cells. It induces antigen-specific immune responses and protects against sporozoite challenge.
- Alza (Johnson & Johnson) and Inovio are developing a DNA malaria vaccine encoding CSP and HEP17 antigens to be delivered by in vivo electroporation-enhanced injection.
- The Entrez Gene ID for hepatocyte erythrocyte protein 17 kDa, Plasmodium yoelii is 3790041.
peripherin 2 (retinal degeneration, slow)
Peripherin 2 is a member of the tetraspanin family of proteins that mediate signal transduction events, which play a role in the regulation of cell development, activation, growth and motility. Peripherin 2 is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis and defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic.
- Copernicus Therapeutics is developing gene therapy systems for the treatment of retinal degeneration conditions, using non-viral compacted DNA-nanoparticle vectors.
- NAE belongs to the Enzyme Target Family Group and its EC number is 6.3.2.
- The Entrez Gene ID for peripherin 2 is 5961.
potassium inwardly-rectifying channel, subfamily J, member 2
Potassium inwardly-rectifying channel, subfamily J, member 2 (KCNJ2) is an integral membrane protein that has a greater tendency to allow potassium to flow into, rather than out of a cell. It is thought to participate in establishing action potential waveform and excitability of neuronal and muscle tissues.
- Intrexon is developing gene therapies for progressive neural disorders.
- KCNJ2 is a member of the Ion Channel > Potassium channel Target Family Group.
- Its Entrez Gene ID is 3759.
SLAM family member 6
SLAM family member 6 is a type I transmembrane CD2-related cell surface protein, expressed on Natural killer (NK), T, and B lymphocytes thus also termed NTB-A. It may function as a coreceptor in the process of NK cell activation. It also mediates inhibitory signals in NK cells from X-linked lymphoproliferative patients.
- Nuvelo is developing a series of MAbs targeting NTB-A for the treatment of B-cell malignancies.
- The Entrez Gene ID for NTB-A is 114836.
v-raf murine sarcoma 3611 viral oncogene homologue
v-raf murine sarcoma 3611 viral oncogene homologue (a-raf) is a member of the v-raf oncogene involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
- Novartis is developing a small-molecule Raf and VEGFR kinase inhibitor for the treatment of cancer.
- a-raf belongs to the Enzyme > Kinase Target Family Group.
- Its Entrez Gene ID is 369.
