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July 2009 Drug Protein Targets

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Required for initiation of translation, the eukaryotic initiation factor 2 (eIF2) consists of an alpha, beta and gamma subunit. Phosphorylation of the alpha subunit (EIF2S1) regulates the rate of formation of eIF2.

tumor necrosis factor (ligand) superfamily, member 14

Also known as TNFSF14, this protein activates NFKB and stimulates the proliferation of T-cells. It acts as a receptor for herpes simplex virus.

midkine (neurite growth-promoting factor 2)

Midkine (neurite growth-promoting factor 2) (MK, MDK or NEGF) is a heparin-binding growth factor that has angiogenic, mitogenic and chemotactic activities. Increased expression of midkine has been observed in numerous cancer types.

CD300 molecule-like family member f

CD300 molecule-like family member f (CD300LF) is a member of the Ig family of receptors. It acts as an inhibitory receptor for myeloid and mast cells and possibly inhibits osteoclast formation.

LMP-1, Epstein-Barr virus

Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) is a transmembrane protein involved in the conversion of B-lymphocytes into indefinitely proliferating lymphoblastoid cell lines. It acts as a CD40 functional homologue that leads to the up-regulation of anti-apoptotic proteins.

LMP-2A, Epstein-Barr virus

Epstein-Barr virus (EBV) latent membrane protein 2A (LMP-1) is a transmembrane protein that maintains EBV infection of B-lymphocytes. It acts as a molecular scaffold to recruit LYN and SYK tyrosine kinase and E3 protein-ubiquitin ligases which leads to the ubiquitination and possibly degradation of both tyrosine kinases.

CD79b molecule, immunoglobulin-associated beta

CD79 is composed of 2 separate proteins CD79a and CD79b. CD79 forms a complex with the B-cell receptor and leads to a signalling cascade following recognition of antigen by the B-cell receptor.

interleukin 17F

Commonly known as IL17F, this protein is predominantly expressed on activated T-cells. Research has shown it can stimulate the production of other cytokines such as IL-6, IL-8 and colony-stimulating factor and inhibit angiogenesis.

fibroblast growth factor 23

Also known as FGF23, this protein plays a role in phosphate metabolism. Defects in FGF23 are known to cause autosomal dominant hypophosphataemic rickets and hyperphosphataemic familial tumoural calcinosis, while mutations cause familial tumoural calcinosis with hyperphosphataemia. Increased expression has been observed in hypophosphataemic osteomalacia.

retinol binding protein 4, plasma

More commonly referred to as RBP4, this lipoprotein is a carrier for retinol in the blood. It delivers retinol from liver stores to peripheral tissues. Defects in RBP4 are associated with retinol-binding protein deficiency.

nuclear receptor co-repressor 2

Nuclear receptor co-repressor 2 (NCOR2 or SMRT) is a transcriptional regulatory protein. A role in the recruitment of histone deacetylases to DNA promoter regions has been proposed.

activated leukocyte cell adhesion molecule

ALCAM or CD166 is a cell adhesion molecule which binds CD6. It may be involved in the binding of T- and B-cells to activated leukocytes and in interactions between cells of the nervous system.

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