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September 2008 Drug Protein Targets

deoxycytidine kinase

Deoxycytidine kinase (DCK) is required for the phosphorylation of the deoxyribonucleosides deoxycytidine deoxyguanosine and deoxyadenosine. It is also involved in the activation of many nucleoside analogues commonly used as antivirals and chemotherapeutics.

C-type lectin domain family 9, member A

Also referred to as CLEC9A or DNGR-1, this protein is a group V C-type lectin-like receptor that acts as an activation receptor. Evidence suggests it is expressed on dendritic cells known to be involved in cross presentation of foreign and self-antigens.

Bernardinelli-Seip congenital lipodystrophy 2 (seipin)

This protein, more commonly referred to as BSCL2 or seipin, is an integral membrane protein of the endoplasmic reticulum. Research supports a role in the regulation of a gene involved in lipid metabolism. Mutations in seipin are associated with Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance.

bone gamma-carboxyglutamate (gla) protein

Bone gamma-carboxyglutamate (gla) protein (BGLAP or osteocalcin) is associated with the bone matrix and is known to play an important role in bone formation. Research indicates roles in the regulation of blood glucose and fat deposits. It may also raise insulin sensitivity and cause insulin release from the pancreas.

neuroblastoma RAS viral (v-ras) oncogene homologue

This membrane protein, also known as NRAS, is commonly found in the Golgi apparatus and the plasma membrane, transfer between these two locations is believed to be controlled by palmitoylation and depalmitoylation. It has GTP/GDP binding and GTPase activity and may play a role in the regulation of normal cell growth. Mutations in NRAS are a known cause of a variety of cancers.

phosphoinositide-3-kinase, catalytic, beta polypeptide

Also referred to as PIK3CB, this protein is a 110-kD catalytic subunit of PI3k. PI3 kinases are commonly deregulated in cancer. They have been implicated as participants in signalling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli.