Oct2007 Drug Protein Targets
angiopoietin 1
Angiopoietin 1 is a secreted glycoprotein growth factor that plays an important role in the maturation of blood vessels by enhancing endothelial cell survival and capillary morphogenesis. By binding and activating the Tie2 receptor, it mediates interactions between the endothelium, surrounding matrix and mesenchyme.
- Multi Gene Vascular Systems is developing a cell therapy product in which cells from short vien segments are activated by insertion of VEGF and angiopoietin-1, and reinserted into the patient for the treatment of PAD.
- The Entrez Gene ID for angiopoietin 1 is 284.
inducible T-cell co-stimulator ligand
This ligand is a B7-related glycoprotein (B7RP-1) that plays an important functional role in the activation of memory T-cells by endothelial cells.
- Amgen is developing a fully-human MAb that binds to B7RP-1 and prevents functional interaction with ICOS on activated T-cells for the treatment of systemic lupus erythrematosus.
- The Entrez Gene ID for B7RP-1 ligand is 23308.
- Cancer Research Technology is developing protein kinase D inhibitors for the treatment of cancer.
- Protein kinase D1 belongs to the Enzyme > Kinase Target Family Group. Its EC number is 2.7.11.17. The Entrez Gene ID for protein kinase D1 is 5587.
- Cancer Research Technology is developing a series of protein kinase C iota inhibitors for the treatment of cancer.
- Protein kinase C, iota belongs to the Enzyme > Kinase Target Family Group. Its EC number is 2.7.11.13. The Entrez Gene ID for protein kinase C, iota is 5584.
- Cancer Research Technology is developing protein kinase N1 inhibitors for the treatment of prostate cancer.
- Protein kinase N1 belongs to the Enzyme > Kinase Target Family Group. Its EC number is 2.7.11.1. The Entrez Gene ID for protein kinase N1 is 5585.
- Kaketsuken is developing a recombinant ADAMTS13 for the treatment of TTP.
- ADAMTS13 belongs to the Enzyme > Protease/peptidase Target Family Group. Its EC number is 3.4.24. The Entrez Gene ID for ADAMTS13 is 11093.
protein kinase D1
This is sometimes known as protein kinase C mu, as it was originally identified as a serine/theronine protein kinase member of of the protein kinase C family. It was subsequently reclassified as calcium/calmodulin-dependent protein kinase family due to sequence similiarities of the kinase domain. It is required for numerous cellular processes and plays an important role in the promotion of cancer.
protein kinase C, iota
Protein kinase C, iota is a calcium-independent, phospohlipid-dependent protein kinase. It protects leukaemia cells against drug-induced apoptosis as it is necessary for Bcr/Abl-mediated resistance to drug-induced apoptosis. It has also been reported to be an oncogene in nsclc.
protein kinase N1
This is a serine/threonine kinase signalling molecule that binds to the androgen recpetor and promotes androgen receptor-dependent transcription. Its levels are upregulated in prostate cancer.
ADAMTS 13
The gene for ADAMTS13 encodes a member of the disintegrin and metalloproteinase with thrombospondin motif protein family. It is a metallopeptidase that plays a critical role in blood coagulation and is the von Willebrand Factor (vWF)-cleaving protease. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura (TTP).
Pharmaprojects - New protein targets for drug development
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