Dec2007 Drug Protein Targets
protease, serine, 12 (neurotrypsin, motopsin)
Neurotrypsin is an extracellular multidomain member of the trypsin family of serine proteases. It is expressed in the central nervous system and research has shown potential roles in agrin cleavage and structural reorganizations linked with the storage of learned behaviours and memories. Mutations in neurotrypsin are associated with mental retardation.
- Neurotune is developing a series of neurotrypsin inhibitors for the treatment of sarcopenia.
- Neurotrypsin belongs to the Enzyme > Protease/peptidase Target Family Group and its EC number is 3.4.21. Its Entrez Gene ID is 8492.
glutamate receptor, metabotropic 4
Metabotropic glutamate receptor 4 (mGluR4) is key neurotransmitter and belongs to the Group III family of metabotropic glutamate receptors - also including mGluR6, -7 and -8 - which are linked to the inhibition of the cyclic AMP cascade. It has been demonstrated that mGluR4 activation triggers a compensatory mechanism that may potentiate the use of dopamine receptor activators, and that it may also have a neuroprotective effect to preserve dopaminergic neurons.
- Addex is developing a series of positive allosteric modulators (PAMs) of mGluR4 for the treatment of Parkinson's disease.
- mGluR4 belongs to the Receptor > GPCR > Metabotropic glutamate Target Family Group. Its Entrez Gene ID is 2914.
Pharmaprojects - New protein targets for drug development
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