Therapy Analysis
- Exon Skipping & Nonsense Suppression
Dec 2009
A joint revolution in the treatment of genetic disease? - Human papillomavirus
Nov 2009
Human papillomavirus (HPV) is a virus that infects the epidermis and mucous membranes in humans. It belongs to the family papillomaviridae, a family of non-enveloped viruses... more - Epilepsy
Jul 2009
Epilepsy is a common chronic neurological disorder that affects people of all ages. The term epilepsy has its root in the Greek epilambanein, meaning "to seize or attack", and represents a large group of disorders... more - Influenza - A persistent threat
Jun 2009
Nobel laureate Joshua Lederberg once commented that "the single biggest threat to man's continued dominance on the planet is the virus". Throughout recent history, few viruses have had such a global impact as influenza... more - Pharma R&D Annual Review
May 2009
May is the time when Pharmaprojects' Annual Review of trends in pharmaceutical R&D is traditionally conducted. It is a useful opportunity to pause and reflect on how the industry is continuing to evolve, and is also the time when we take the annual snapshot of our data which provides a new timepoint for our Trends data module. In this article, we examine the data for 2009, look at how it has changed since 2008, and try to put the information into some sort of context... more - Gene Therapy - Still the next big thing?
April 2009
Normal pharmacological treatment of disease seeks to correct aberrant biochemistries in the body via the proper application of agents to counteract these problems. Gene therapy however, goes one step further, and actually acts upon the root cause of target diseases - correction of the 'faulty' DNA itself... more - Sleep, A Mental Mystery
February 2009
While the boundaries of neuroscience are constantly being pushed back and new information about that most enigmatic of organs, the human brain, uncovered almost daily it seems, we still do not fully understand the fundamentals of one of the most common and routine actions to which we all are slaves - namely our need to sleep... more - The potential of P2 Purinoreceptors
January 2009
Purinoreceptors are the cell-surface receptors for the nucleotides adenosine, ATP, ADP, UTP and UDP. This review will highlight drug discovery based on the receptors activated by ATP - a class known as the P2 purinoceptors... more - New indications for old drugs
December 2008
The process of bringing novel pharmaceuticals to the market is becoming an increasingly costly business. Even for the giants of Big Pharma, delivering novel and profitable drugs to offset the ever-spiralling cost of pharmaceutical research is a delicate balancing act, one with huge financial risks involved... more - Depression and affective disorders
November 2008
Depression is a complex and often misunderstood disease, coming as it does in many guises, ranging from bipolar disorder to major depressive disorder, dysthymia and post-natal depression... more - Asthma: From corticosteroids to leucotriene agonists and beyond
October 2008
Asthma is a common disease, and the number of sufferers seems to be on the rise. Asthma affects one in five households in the UK, of which 5.2 million are seeking treatment... more - The role of Toll-like receptors as a target for therapeutics
September 2008
It is well-established that the innate immune system is essential to human survival, providing the first line of defence by recognizing and responding to pathogenic threats when microorganisms breach the body's barriers... more - microRNA: Micro-Management
August 2008
How microRNA could revolutionize traditional thinking on targeted drug development... more - Antibiotic-resistance: fighting the superbugs
July 2008
In 1928 in a basement laboratory of St Mary's Hospital, London, microbiologist Alexander Fleming noticed a halo of inhibition of growth around a culture of Staphylococcus aureus bacteria that had been contaminated by a blue-green mould... more - Telomerase as a potential therapeutic target
June 2008
The significance of cancer in the modern world needs no introduction. 7.6 million people died from cancer in 2007, accounting for roughly 13% of all deaths. In some Western countries such as the USA and the UK, cancer is now overtaking cardiovascular disease as the leading cause of death... more - Pharma R&D Annual Review
May 2008
Pharmaprojects' 2008 annual review of trends in pharmaceutical R&D appears to show the largest expansion in pipeline size ever recorded, despite disappointingly few new active substances (NASs) reaching the market... more - Sickle cell anaemia: breaking the sickle cycle
Mar 2008
In 1904, dental student Walter Noel was hospitalized with severe respiratory distress. Over the next 2 and a half years, Noel was readmitted several times for muscular rheumatism and bilious attacks. In routine blood analysis, his physician Dr Ernest Irons discovered some of his red blood cells (RBCs) to be "peculiarly elongated and sickle cell shaped". Baffled by this strange observation... more - Anticancer drugs - where are we now?
Jan 2008
In 1971, in response to pressure from the American people, President Nixon announced a 'War on Cancer'. He requested an additional US$100m budget for cancer research and converted the Army's Fort Detrick biological warfare facility into the Frederick Cancer Research and Development Center, now internationally recognised for its cancer and AIDS research... more - Vision for the future: upcoming therapies for the treatment of AMD
Nov 2007
Age-related macular degeneration (AMD) accounts for nearly 50% of all visual impairment in the developed world. It is associated with adults over the age of 50, and is characterized by thinning and atrophy of the macula... more - Malaria - An ongoing Challenge
Sept 2007
Malaria is one of the largest health crises facing the world today, with 400-900 million people becoming infected with the disease each year, resulting in over a million deaths annually... more - Drug addiction: kicking the habit
July 2007
Drug addiction is the compulsive dependence on a substance, either legal or illegal, characterized by compulsive drug consumption with associated loss of control in limiting intake, craving and surfacing of an emotional state in the absence of the drug... more - Pharma R&D Annual Review
May 2007
Pharmaprojects' 2007 annual review of trends in pharmaceutical R&D appears to indicate a renewed expansion in pipeline size over the past twelve months, despite a continuing dearth of new active substances (NASs) reaching the market... more - Hearing loss & tinnitus
Apr 2007
Since the invention of the first electric guitar in the 1920s, the technological revolution has changed the face of music. With the ability to amplify music to high volumes whilst maintaining incredible sound quality... more - Anorexia & bulimia: dying to be slim
Mar 2007
It appears to be all the rage; Nicole Richie has one, Calista Flockhart had one, as did Geri Halliwell, Mary-Kate Olsen and even our own dear Princess Diana... more - Chlamydia, gonorrhoea and syphilis: the battle against bacterial STIs
Feb 2007
Bacterial sexually-transmitted infections (STIs) now exist in epidemic proportions, causing a clear and significant health and economic impact worldwide.... more - The impact of skin disorders: Psoriasis and skin cancer
Jan 2007
Human skin, the largest organ, is an important visual communication tool, serving also to display how healthy we are. A recent study proposed that the evolution of colour vision in primates... more - Leishmaniasis: an old plague for a new world
Dec 2006
An estimated 2 million people become infected with the Leishmania parasite every year. The resulting disease lacks notoriety, particularly as it occurs most frequently in developing countries, but it is nevertheless well documented... more - Harder to breathe: living with asthma
Nov 2006
For the millions of people who are unfortunate enough to suffer from the chronic lung disease asthma, struggling to breathe is something of a regular - even daily - experience... more
