| Position 2008 (2007) | Pharmacological activity (code) | No of products 2008 (2007) | % PR, R or L |
|---|---|---|---|
| 1 (1) | Immunostimulant (IM-) | 888 (750) | 10 |
| 2 (3) | Apoptosis agonist (APOP+) | 199 (159) | 4 |
| 3 (2) | Angiogenesis inihibitor (ANGG-) | 186 (162) | 8 |
| 4 (-) | Cell cycle inhibitor (CELL-CY-) | 128 (-) | 13 |
| 5 (4) | DNA antagonist (DNA-) | 114 (107) | 17 |
| 6 (5) | Immunosuppressant (IM-) | 95 (76) | 25 |
| 7 (6) | Topoisomerase 2 inhibitor (TO-2-) | 85 (72) | 20 |
| 8 (7) | Cyclooxgenase 2 inhibitor (OX-C-2-) | 77 (66) | 42 |
| 9 (8) | Sodium channel antagonist (CHA-NA-) | 70 (61) | 26 |
| 10 (9) | Cell wall synthesis antagonist (SY-CW-) | 65 (55) | 32 |
| 11 (-) | Mitotic inhibitor (MITOT-) | 65 (-) | 14 |
| 12 (-) | Glucocorticoid agonist (COR-G+) | 63 (-) | 37 |
| 13 (16) | Opioid µ agonist (OPI-M+) | 62 (50) | 31 |
| 14 (20) | Gene expression inhibitor (GE-EXP-) | 59 (47) | 0 |
| 15 (17) | Estrogen agonist (ESTR+) | 58 (50) | 48 |
| 16 (18) | Cyclooxygenase 1 inhibitor (OX-C-1) | 58 (50) | 48 |
| 17 (13) | Tumour necrosis factor α antagonist (TNF-A-) | 57 (54) | 19 |
| 18 (10) | Microtubule stimulant (MICTUBE+) | 55 (54) | 15 |
| 19 (15) | 5-HT reuptake inhibitor (5HTU-) | 53 (50) | 36 |
| 20 (14) | Microtubule inhibitor (MICTUBE-) | 53 (51) | 4 |
| Table 4: Top 20 pharmacological activities. | |||